FAS-1377 G/A (rs2234767) Polymorphism and Cancer Susceptibility: A Meta-Analysis of 17,858 Cases and 24,311 Controls
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چکیده
منابع مشابه
FAS-1377 G/A (rs2234767) Polymorphism and Cancer Susceptibility: A Meta-Analysis of 17,858 Cases and 24,311 Controls
BACKGROUND AND OBJECTIVES Disruption of apoptosis has been implicated in carcinogenesis. Specifically, various single-nucleotide polymorphisms (SNPs) in apoptotic genes, such as FAS-1377 G/A SNP, have been associated with cancer risk. FAS-1377 G/A SNP has been shown to alter FAS gene promoter transcriptional activity. Down-regulation of FAS and cell death resistance is key to many cancers, but ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0073700